Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): an updated review
The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell
Z Yang, D Luo, C Shao, H Hu, X Yang, Y Cai… - European Journal of …, 2024 - Elsevier
The inhibition of P-glycoprotein (P-gp) has emerged as an intriguing strategy for
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
circumventing multidrug resistance (MDR) in anticancer chemotherapy. In this study, we …
Chaetoxylariones A–G: undescribed chromone-derived polyketides from co-culture of Chaetomium virescens and Xylaria grammica enabled via the molecular …
S Zhang, L Gu, Y Lin, H Zeng, N Ding, J Wei, X Gu… - Bioorganic …, 2024 - Elsevier
By co-culturing two endophytic fungi (Chaetomium virescens and Xylaria grammica)
collected from the medicinal and edible plant Smilax glabra Roxb. and analyzing them with …
collected from the medicinal and edible plant Smilax glabra Roxb. and analyzing them with …
Discovery of 2, 5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell
Z Yang, Y Cai, S Mao, Q Wu, M Zhu, X Cao… - European Journal of …, 2023 - Elsevier
Abstract P-glycoprotein (P-gp) is one of the drug efflux transporters that triggers multidrug
resistance (MDR) in cells. Herein, by utilizing the strategies of active skeleton splicing and …
resistance (MDR) in cells. Herein, by utilizing the strategies of active skeleton splicing and …
Novel pyxinol amide derivatives bearing an aliphatic heterocycle as P-glycoprotein modulators for overcoming multidrug resistance
L Yu, R Ren, S Li, C Zhang, C Chen, H Lv, Z Zou… - European Journal of …, 2024 - Elsevier
P-glycoprotein (Pgp) modulators are promising agents for overcoming multidrug resistance
(MDR) in cancer chemotherapy. In this study, via structural optimization of our lead …
(MDR) in cancer chemotherapy. In this study, via structural optimization of our lead …
Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based …
T Yu, R Zeng, Y Guan, B Pan, HW Li, J Gu… - RSC Medicinal …, 2024 - pubs.rsc.org
The discovery of novel and highly effective P-gp inhibitors is considered to be an effective
strategy for overcoming tumor drug resistance. In this paper, a phenotypic screening via a …
strategy for overcoming tumor drug resistance. In this paper, a phenotypic screening via a …
Molecular Modeling Studies to Probe the Binding Hypothesis of Novel Lead Compounds against Multidrug Resistance Protein ABCB1
Y Cheema, KJ Linton, I Jabeen - Biomolecules, 2024 - mdpi.com
The expression of drug efflux pump ABCB1/P-glycoprotein (P-gp), a transmembrane protein
belonging to the ATP-binding cassette superfamily, is a leading cause of multidrug …
belonging to the ATP-binding cassette superfamily, is a leading cause of multidrug …