Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Over 75% of malaria-attributable deaths occur in children under the age of 5 years.
However, the first malaria vaccine recommended by the World Health Organization (WHO) …

Background Human monoclonal antibodies might offer an important new approach to
reduce malaria morbidity and mortality. In the first two parts of a three-part clinical trial, the …

Recent advances in malaria genetics and genomics have transformed many aspects of
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …

Human monoclonal antibodies (mAbs) against the central repeat and junction domain of
Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to …

Background Plasmodium vivax has been more resistant to various control measures than
Plasmodium falciparum malaria because of its greater transmissibility and ability to produce …

Drug discovery for malaria has traditionally focused on orally available drugs that kill the
abundant, parasitic blood stage. Recently, there has also been an interest in injectable …

Malaria, caused by Plasmodium parasites, remains one of the most devastating infectious
diseases worldwide, despite control efforts to lower morbidity and mortality. Both advanced …

Eukaryotic cell adhesion and migration rely on surface adhesins connecting extracellular
ligands to the intracellular actin cytoskeleton. Plasmodium sporozoites are transmitted by …