The MCL1 gene (myeloid cell leukemia-1) was discovered serendipitously about a decade
ago and proved to be a member of the emerging BCL2 gene family. Ongoing studies of this …

Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds
characterizing their targets, effectors, and activity modulators represents a highly relevant yet …

Aim Pancreatic cancer (PC) is one of the most aggressive tumors with dismal survival and a
high death rate due to chemotherapeutic failure. P-glycoprotein (P-gp) plays a pivotal role in …

Although many studies have shown the antitumor properties of ginger extract (Zingiber
officinale), little is known regarding the mechanism of its effects. This study was conducted to …

Abstract CPT-11, a DNA topoisomerase I inhibitor, and oxaliplatin, a diaminocyclohexane
platinum derivative, are cytotoxic agents that have demonstrated clinical antitumor activity in …

The present study explored the effects of three commonly used chemotherapeutic agents on
the Bcl‐2/Bax apoptosis pathway and the interaction of these chemotherapeutic drugs with …

Background Human colon cancers have a high frequency of p53 mutations, and cancer cells
expressing mutant p53 tend to be resistant to current chemo-and radiation therapy. It is thus …

The diagnosis and treatment for colon cancer have been greatly developed, but the
prognosis remains unsatisfactory. There is still a great clinical need to explore new …

DNA damage and environmental stress activate signaling and induce genes involved in cell
cycle and cell death. Expression of the Gadd45 protein is induced following DNA damage …

PURPOSE: To examine the apoptotic effect induced in human retinoblastoma Y79 cells by
camptothecin, etoposide, and amsacrine, to examine the effect of these drugs on the …