During evolution, the development of bone was critical for many species to thrive and
function in the boundary conditions of Earth. Furthermore, bone also became a storehouse …

Personalised medicine and the development of a virtual human or a digital twin comprises
visions of the future of medicine. To realise these innovations, an understanding of the …

Declining physical performance with age and disease is an important indicator of declining
health. Biomarkers that identify declining physical performance would be useful in predicting …

Introduction Heterotopic ossification (HO) is a complex pathology often observed in combat
injured casualties who have sustained severe, high energy polytraumatic extremity injuries …

There is limited empirical evidence on whether Coronavirus disease 2019 (COVID-19)
related lockdown restrictions precipitate or perpetuate musculoskeletal (MSK) disorders …

For much of human evolution, the average lifespan was< 40 years, due in part to disease,
infant mortality, predators, food insecurity, and, for females, complications of childbirth. Thus …

Bisphosphonates are a class of drugs which have shown good efficacy in the treatment of
post‐menopausal osteoporosis, as well as a good safety profile. However, side‐effects such …

Reproduction via cis-binary mechanisms appears to have evolved fairly early in the
evolution of complex organisms, and a system committed to prior to evolution of humans …