Context Although little is known as yet about the processes that coordinate cell-signalling
pathways, matrix proteins are probably major players in this type of global control. The CCN …

The CCN proteins are key signalling and regulatory molecules involved in many vital
biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound …

Regeneration of CNS myelin involves differentiation of oligodendrocytes from
oligodendrocyte progenitor cells. In multiple sclerosis, remyelination can fail despite …

Coordinated production and remodeling of the extracellular matrix is essential during
development. It is of particular importance for skeletogenesis, as the ability of cartilage and …

Background Connective tissue growth factor (CTGF) is widely thought to promote the
development of fibrosis in collaboration with transforming growth factor (TGF)-β; however …

CYR61 (CCN1) is a member of the CCN family of secreted matricellular proteins that
includes connective tissue growth factor (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 …

We compared and contrasted the mechanism of action for the cysteine knot protein
subfamily, Wise and Sost (Sclerostin). Our data suggest that functional interactions between …

Connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61) are prototypical
members of the CCN family which also contains nephroblastoma overexpressed (NOV) and …

Le facteur de croissance du tissu conjonctif (CTGF, CCN2), un membre de la famille des
protéines CCN, est une protéine de la matrice cellulaire pro-adhésive riche en cystéine qui …

Connective tissue growth factor (CTGF/CCN2) is a highly profibrogenic molecule which is
overexpressed in many fibrotic lesions, including those of the liver. CTGF/CCN2 is …