Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

The morphological diversity of animals, fungi, plants, and other multicellular organisms
stems from the fact that each lineage acquired multicellularity independently. A prerequisite …

Apoptotic cell death is important for embryonic development, immune cell homeostasis, and
pathogen elimination. Innate immune cells also undergo a very rapid form of cell death …

The increasing use of nanoparticles in medicine has raised concerns over their ability to
gain access to privileged sites in the body. Here, we show that cobalt–chromium …

The mechanisms involved in Alzheimer's disease are not completely understood and how
glial cells contribute to this neurodegenerative disease remains to be elucidated. Because …

Extracellular ATP controls various signaling systems including propagation of intercellular
Ca2+ signals (ICS). Connexin hemichannels, P2x7 receptors (P2x7Rs), pannexin channels …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Connexins constitute a large family of trans-membrane proteins that allow intercellular
communication and the transfer of ions and small signaling molecules between cells …

The cells of most mammalian organs are connected by groups of cell-to-cell channels called
gap junctions. Gap junction channels are made from the connexin (Cx) family of proteins …

Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium,
calcium, potassium, and chloride channels and fire action potentials spontaneously …