Abstract Purpose of Review This review aims to highlight recent advances in understanding
the genetic basis of intervertebral disc degeneration (IDD). Recent Findings It has been …

Disc degeneration is a condition that compromises the intervertebral disc functions, which
can lead to several important pathological processes, such as disc herniation and canal …

Intervertebral disk degeneration (IDD) is a major cause of low back pain that becomes a
prevalent age‐related disease. However, the pathophysiological processes behind IDD are …

Objective: To investigate the relationship between serum vitamin D concentration and
lumbar disc degeneration (LDD) in postmenopausal women and the epidemiologic factors …

Purpose Numerous candidate genes and single-nucleotide polymorphisms (SNPs) have
been identified in the background of lumbar disc degeneration (LDD). However, in most of …

Background An increasing number of studies have investigated associations between
collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene …

Background Lumbar disk disease (LDD) is a common musculoskeletal disorder. Several
predisposing genetic and environmental risk factors have been established for symptomatic …

Background: Numerous studies have investigated the associations between Vitamin D
receptor (VDR) gene polymorphisms and risk of intervertebral disc degeneration but the …

Vitamin D is known to have immunomodulatory effects, is involved in osteo-cartilaginous
metabolism, and may have a role in human intervertebral disc pathophysiology. Although a …

Intervertebral disc (IVD) degeneration is a progressive and painful pathology that can root
from mechanical, biochemical, and environmental stressors. However, recent advancements …