Enhanced precision and efficiency in metabolic regulation: compartmentalized metabolic engineering
R Wang, Y Su, W Yang, H Zhang, J Wang… - Bioresource Technology, 2024 - Elsevier
Metabolic engineering has witnessed remarkable advancements, enabling successful large-
scale, cost-effective and efficient production of numerous compounds. However, the …
scale, cost-effective and efficient production of numerous compounds. However, the …
Unveiling the multifaceted world of anthocyanins: Biosynthesis pathway, natural sources, extraction methods, copigmentation, encapsulation techniques, and future …
Numerous datasets regarding anthocyanins have been noted elsewhere. These previous
studies emphasized that all processes must be carried out meticulously from the source …
studies emphasized that all processes must be carried out meticulously from the source …
Evolution and diversification of carboxylesterase-like [4+ 2] cyclases in aspidosperma and iboga alkaloid biosynthesis
MD DeMars, SE O'Connor - Proceedings of the National …, 2024 - National Acad Sciences
Monoterpene indole alkaloids (MIAs) are a large and diverse class of plant natural products,
and their biosynthetic construction has been a subject of intensive study for many years. The …
and their biosynthetic construction has been a subject of intensive study for many years. The …
Peroxisome-based metabolic engineering for biomanufacturing and agriculture
Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic
engineering. The peroxisome has emerged as a highly valuable and promising …
engineering. The peroxisome has emerged as a highly valuable and promising …
Reconstitution and optimization of complex plant natural product biosynthetic pathways in microbial expression systems
J Gao, Y Gou, L Huang, J Lian - Current Opinion in Biotechnology, 2024 - Elsevier
Highlights•Microbial expression systems for sustainable production of plant natural
products.•Multiplex genome editing for rapid construction of complex PNP biosynthetic …
products.•Multiplex genome editing for rapid construction of complex PNP biosynthetic …
[HTML][HTML] Plant synthetic biology for human health: advances in producing medicines in heterologous expression systems
R Sadre - Current Opinion in Biotechnology, 2024 - Elsevier
Highlights•The “triple P” concept drives plant engineering for high-value natural
products.•Artificial organelles offer new opportunities to boost plant natural product …
products.•Artificial organelles offer new opportunities to boost plant natural product …
Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis
XX He, YJ Huang, CL Hu, QQ Xu, QJ Wei - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Osteoarthritis (OA) is a prevalent joint disorder characterized by multifaceted
pathogenesis, with macrophage dysregulation playing a critical role in perpetuating …
pathogenesis, with macrophage dysregulation playing a critical role in perpetuating …
Functional characterization of polyphenol oxidase OfPPO2 supports its involvement in parallel biosynthetic pathways of acteoside
Y Liu, X Han, M Zhao, L Liu, Z Deng, Q Zhao… - The Plant …, 2024 - Wiley Online Library
Acteoside is a bioactive phenylethanoid glycoside widely distributed throughout the plant
kingdom. Because of its two catechol moieties, acteoside displays a variety of beneficial …
kingdom. Because of its two catechol moieties, acteoside displays a variety of beneficial …
Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa
Y Chen, JP Huang, YJ Wang, ML Tu, J Li… - Journal of Integrative …, 2024 - Wiley Online Library
Camptothecin is a complex monoterpenoid indole alkaloid with remarkable antitumor
activity. Given that two C‐10 modified camptothecin derivatives, topotecan and irinotecan …
activity. Given that two C‐10 modified camptothecin derivatives, topotecan and irinotecan …
[PDF][PDF] Evolution and diversification of carboxylesterase-like [4+ 2] cyclases in aspidosperma and iboga alkaloid biosynthesis
MDDM IIa, SE O'Connora - 2024 - pure.mpg.de
On the basis of their primary amino acid sequences, the cyclases from C. roseus and T.
iboga are classified as 2-hydroxyisoflavanone dehydratase (HID)-like proteins. In …
iboga are classified as 2-hydroxyisoflavanone dehydratase (HID)-like proteins. In …