Cu (I)-catalyzed click chemistry in glycoscience and their diverse applications

AK Agrahari, P Bose, MK Jaiswal, S Rajkhowa… - Chemical …, 2021 - ACS Publications
Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Bioorthogonal chemistry

SL Scinto, DA Bilodeau, R Hincapie, W Lee… - Nature Reviews …, 2021 - nature.com
Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

A hitchhiker's guide to click-chemistry with nucleic acids

NZ Fantoni, AH El-Sagheer, T Brown - Chemical Reviews, 2021 - ACS Publications
Click chemistry is an immensely powerful technique for the fast and efficient covalent
conjugation of molecular entities. Its broad scope has positively impacted on multiple …

Cu-catalyzed click reaction in carbohydrate chemistry

VK Tiwari, BB Mishra, KB Mishra, N Mishra… - Chemical …, 2016 - ACS Publications
Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

Macrocyclization strategies for cyclic peptides and peptidomimetics

C Bechtler, C Lamers - RSC Medicinal Chemistry, 2021 - pubs.rsc.org
Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Click chemistry in proteomic investigations

CG Parker, MR Pratt - Cell, 2020 - cell.com
Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

E Haldón, MC Nicasio, PJ Pérez - Organic & Biomolecular Chemistry, 2015 - pubs.rsc.org
The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed …

Click chemistry in complex mixtures: bioorthogonal bioconjugation

CS McKay, MG Finn - Chemistry & biology, 2014 - cell.com
The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

The CuAAC: Principles, homogeneous and heterogeneous catalysts, and novel developments and applications

S Neumann, M Biewend, S Rana… - Macromolecular Rapid …, 2020 - Wiley Online Library
The copper‐catalyzed azide/alkyne cycloaddition reaction (CuAAC) has emerged as the
most useful “click” chemistry. Polymer science has profited enormously from CuAAC by its …

Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology

KE Sapsford, WR Algar, L Berti, KB Gemmill… - Chemical …, 2013 - ACS Publications
Bionanotechnology has now become firmly established in its own right as one of the
principle and focused subdisciplines within nanotechnology.(1-10) Bionanotechnology can …