Understanding patterns and trends of antimicrobial resistance (AMR) in Salmonella Typhi
can guide empiric treatment recommendations and contribute to country decisions about …

Sickle cell disease (SCD) results in chronic hemolytic anemia, recurrent vascular occlusion,
insidious vital organ deterioration, early mortality, and diminished quality of life. Life …

Cancer vaccines based on resected tumors from patients have gained great interest as an
individualized cancer treatment strategy. However, eliciting a robust therapeutic effect with …

Background Typhoid fever remains a major cause of morbidity and mortality in low-income
and middle-income countries. Vi-tetanus toxoid conjugate vaccine (Vi-TT) is recommended …

Background In 2017, more than half the cases of typhoid fever worldwide were projected to
have occurred in India. In the absence of contemporary population-based data, it is unclear …

Background Enteric fever is a serious public health concern in many low-income and middle-
income countries. Numerous data gaps exist concerning the epidemiology of Salmonella …

Background Typhoid fever is a major public health problem in low-resource settings.
Vaccination can help curb the disease and might reduce transmission. We have previously …

Summary Background Salmonella enterica serotype Typhi (S Typhi) is a major public health
problem in low-income and middle-income countries. We aimed to investigate the …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Typhoid Vi vaccines have been shown to be efficacious in children living in endemic
regions; however, a widely accepted correlate of protection remains to be established. We …