Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

The retraction of> 30 falsified studies by Anversa et al. has had a disheartening impact on
the cardiac cell therapeutics field. The premise of heart muscle regeneration by the …

Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …

Cardiovascular disease is a leading cause of death worldwide, and thus there remains great
interest in regenerative approaches to treat heart failure. In the past 20 years, the field of …

Background Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular
childhood disorder that causes progressive muscle weakness and degeneration and results …

The periosteum is the major source of cells involved in fracture healing. We sought to
characterize progenitor cells and their contribution to bone fracture healing. The periosteum …

A major hurdle in cardiac cell therapy is the lack of a bona fide autologous stem-cell type
that can be expanded long-term and has authentic cardiovascular differentiation potential …

The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …

Myocardial infarction is the first cause of worldwide mortality, with an increasing incidence
also reported in developing countries. Over the past decades, preclinical research and …

The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage
relationships within cardiac stromal cells are poorly defined. Here, we identified heart …