Improving translation of animal models of addiction and relapse by reverse translation
Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …
animal models, including escalation of drug intake, punished drug seeking and taking …
Astrocyte regulation of synaptic signaling in psychiatric disorders
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
The development of compulsive coping behavior depends on dorsolateral striatum dopamine-dependent mechanisms
Humans greatly differ in how they cope with stress, a natural behavior learnt through
negative reinforcement. Some individuals engage in displacement activities, others in …
negative reinforcement. Some individuals engage in displacement activities, others in …
From compulsivity to compulsion: the neural basis of compulsive disorders
Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
Activation of GABAB receptors in central amygdala attenuates activity of PKCδ + neurons and suppresses punishment-resistant alcohol self-administration in rats
E Domi, L Xu, S Toivainen, J Wiskerke… - …, 2023 - nature.com
Alcohol use despite negative consequences is a core phenomenon of alcohol addiction. We
recently used alcohol self-administration that is resistant to footshock punishment as a …
recently used alcohol self-administration that is resistant to footshock punishment as a …
Environment‐dependent behavioral traits and experiential factors shape addiction vulnerability
M Fouyssac, M Puaud, E Ducret… - European Journal of …, 2021 - Wiley Online Library
The transition from controlled drug use to drug addiction depends on an interaction between
a vulnerable individual, their environment and a drug. Here we tested the hypothesis that …
a vulnerable individual, their environment and a drug. Here we tested the hypothesis that …
Individual differences in the engagement of habitual control over alcohol seeking predict the development of compulsive alcohol seeking and drinking
Excessive drinking is an important behavioural characteristic of alcohol addiction, but not the
only one. Individuals addicted to alcohol crave alcoholic beverages, spend time seeking …
only one. Individuals addicted to alcohol crave alcoholic beverages, spend time seeking …
Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice
NM Timme, CE Ardinger, SDC Weir… - …, 2024 - Elsevier
A key facet of alcohol use disorder is continuing to drink alcohol despite negative
consequences (so called “aversion-resistant drinking”). In this study, we sought to assess …
consequences (so called “aversion-resistant drinking”). In this study, we sought to assess …
Astrocytic GABAergic Regulation in Alcohol Use and Major Depressive Disorders
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central
nervous system (CNS). Most GABAergic neurons synthesize GABA from glutamate and …
nervous system (CNS). Most GABAergic neurons synthesize GABA from glutamate and …
Correlation of striatal dopamine D2/3 receptor availability with GABA level in the anterior cingulate cortex in healthy controls but not in alcohol‐dependent subjects …
G Spitta, T Gleich, A Rosenthal, F Schubert… - Addiction …, 2024 - Wiley Online Library
Background The association of impaired dopaminergic neurotransmission with the
development and maintenance of alcohol use disorder is well known. More specifically …
development and maintenance of alcohol use disorder is well known. More specifically …