The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

The mitochondrial genome (mtDNA) encodes essential machinery for oxidative
phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically …

Spleen is an ideal site for initiating and amplifying antigen-specific immune response.
However, spleen-selective antigen delivery has limited tumor therapeutic efficacy owing to …

Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

The application of nanomaterials in healthcare has emerged as a promising strategy due to
their unique structural diversity, surface properties, and compositional diversity. In particular …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Malignant expansion and rapid metastasis are the main limiting factors to successful
treatment of lung cancer. Messenger RNA (mRNA) tumor vaccines are a promising …