[HTML][HTML] Thiazole ring—A biologically active scaffold
A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …
applications. Its derivatives have a wide range of biological activities such as antioxidant …
[HTML][HTML] Physiological and pathological roles of aldose reductase
M Singh, A Kapoor, A Bhatnagar - Metabolites, 2021 - mdpi.com
Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors
A series of novel sulfonates containing quinazolin‐4 (3 H)‐one ring derivatives was
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
Transition‐metal complexes of bidentate Schiff‐base ligands: in vitro and in silico evaluation as non‐classical carbonic anhydrase and potential acetylcholinesterase …
Schiff bases display superior features for many areas, such as significant intermediates in
industrial biological, pharmacological, catalytic and optical properties, organic synthesis …
industrial biological, pharmacological, catalytic and optical properties, organic synthesis …
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
Abstract Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
N‐substituted phthalazine sulfonamide derivatives as non‐classical aldose reductase inhibitors
Abstract Aldose reductase (AR, AKR1B1; EC 1.1. 1.21) is an aldo‐keto reductase that has
been widely investigated as an enzyme crucially involved in the pathogenesis of several …
been widely investigated as an enzyme crucially involved in the pathogenesis of several …
[HTML][HTML] A new series of 2, 4-thiazolidinediones endowed with potent aldose reductase inhibitory activity
In an effort to identify potent aldose reductase (AR) inhibitors, 5-(arylidene) thiazolidine-2, 4-
diones (1–8), which were prepared by the solvent-free reaction of 2, 4-thiazolidinedione with …
diones (1–8), which were prepared by the solvent-free reaction of 2, 4-thiazolidinedione with …
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …