Synthesis and characterization of Mg-hydroxyapatite and its cellulose hybridized structure as enhanced bio-carrier of oxaliplatin drug; equilibrium and release kinetics

AT Okasha, AA Abdel-Khalek, HA Rudayni… - RSC …, 2023 - pubs.rsc.org
An advanced form of magnesium-doped hydroxyapatite (Mg HAP) was synthesized and
hybridized with cellulose fibers, producing a safe biocomposite (CF/Mg HAP) as an …

Predicting hepatotoxicity associated with low-dose methotrexate using machine learning

Q Hu, H Wang, T Xu - Journal of Clinical Medicine, 2023 - mdpi.com
An accurate prediction of the hepatotoxicity associated with low-dose methotrexate can
provide evidence for a reasonable treatment choice. This study aimed to develop a machine …

Comprehensive Analysis of Fatty Acid Metabolism in Diabetic Nephropathy from the Perspective of Immune Landscapes, Diagnosis and Precise Therapy

E Zhu, M Zhong, T Liang, Y Liu, K Wu… - Journal of …, 2024 - Taylor & Francis
Objective Diabetic nephropathy (DN) represents the principal cause of end-stage renal
diseases worldwide, lacking effective therapies. Fatty acid (FA) serves as the primary energy …

Development of Serum Lactate Level-Based Nomograms for Predicting Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

C Jiang, X Ma, J Chen, Y Zeng, M Guo… - Diabetes, Metabolic …, 2024 - Taylor & Francis
Purpose To establish nomograms integrating serum lactate levels and traditional risk factors
for predicting diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients …

Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors

MT Shehzad, A Imran, A Hameed, M Al Rashida… - RSC …, 2021 - pubs.rsc.org
Inhibition of aldose reductase (ALR2) by using small heterocyclic compounds provides a
viable approach for the development of new antidiabetic agents. With our ongoing interest …

The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies

QY Peng, Y An, ZZ Jiang, Y Xu - Journal of Inflammation Research, 2024 - Taylor & Francis
Diabetic kidney disease (DKD), is a common microvascular complication and a major cause
of death in patients with diabetes. Disorders of immune cells and immune cytokines can …

Recent Progress on Natural α-glucosidase Inhibitors Derived from the Plants and Microorganisms

C Deng, N Zhang, H Lin, W Lu, F Ding… - Current Medicinal …, 2024 - ingentaconnect.com
α-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to
antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of …

A Literature Review Focusing on the Antiviral Activity of [1, 2, 4] and [1, 2, 3]-triazoles

TA Farghaly, GS Masaret, SM Riyadh… - Mini Reviews in …, 2024 - ingentaconnect.com
Out of a variety of heterocycles, triazole scaffolds have been shown to play a significant part
in a wide array of biological functions. Many drug compounds containing a triazole moiety …

Evaluation of benzaldehyde derivatives as being bovine kidney aldose reductase inhibitors

B Şengül - Türk Doğa ve Fen Dergisi, 2023 - dergipark.org.tr
Aldose reductase (AR) catalyzes the production of sorbitol from glucose in the polyol
pathway, and it is a critical enzyme that causes an aberrant aggregation of sorbitol in …

Diabetes Pharmacotherapy and its effects on the Skeletal Muscle Energy Metabolism

B Yu, D Wang, J Zhou, R Huang, T Cai… - Mini Reviews in …, 2024 - ingentaconnect.com
The disorders of skeletal muscle metabolism in patients with Type 2 diabetes mellitus
(T2DM), such as mitochondrial defection and glucose transporters (GLUTs) translocation …