[HTML][HTML] Optogenetics for visual restoration: from proof of principle to translational challenges

M Lindner, MJ Gilhooley, S Hughes… - Progress in retinal and …, 2022 - Elsevier
Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …

Towards the translation of electroconductive organic materials for regeneration of neural tissues

E Manousiouthakis, J Park, JG Hardy, JY Lee… - Acta Biomaterialia, 2022 - Elsevier
Carbon-based conductive and electroactive materials (eg, derivatives of graphene,
fullerenes, polypyrrole, polythiophene, polyaniline) have been studied since the 1970s for …

Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

D Keppeler, M Schwaerzle, T Harczos… - Science Translational …, 2020 - science.org
When hearing fails, electrical cochlear implants (eCIs) provide the brain with auditory
information. One important bottleneck of CIs is the poor spectral selectivity that results from …

Neurophotonic tools for microscopic measurements and manipulation: status report

AS Abdelfattah, S Ahuja, T Akkin, SR Allu… - …, 2022 - spiedigitallibrary.org
Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative
focused on development of technologies for advancement of neuroscience. For the last …

The potential of artificial intelligence for assistive technology in education

K Zdravkova - Handbook on Intelligent Techniques in the Educational …, 2022 - Springer
The right to education is a fundamental human right and an indispensable prerequisite for
the development of human beings. To become well-rounded and independent from others …

[HTML][HTML] Overloaded adeno-associated virus as a novel gene therapeutic tool for otoferlin-related deafness

V Rankovic, C Vogl, NM Dörje, I Bahader… - Frontiers in Molecular …, 2021 - frontiersin.org
Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation
of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear …

[HTML][HTML] Bipolar cell targeted optogenetic gene therapy restores parallel retinal signaling and high-level vision in the degenerated retina

J Kralik, M van Wyk, N Stocker, S Kleinlogel - Communications biology, 2022 - nature.com
Optogenetic gene therapies to restore vision are in clinical trials. Whilst current clinical
approaches target the ganglion cells, the output neurons of the retina, new molecular tools …

μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve

A Dieter, E Klein, D Keppeler, L Jablonski… - EMBO molecular …, 2020 - embopress.org
Electrical cochlear implants (eCIs) partially restore hearing and enable speech
comprehension to more than half a million users, thereby re‐connecting deaf patients to the …

The opportunities and challenges of gene therapy for treatment of inherited forms of vision and hearing loss

EJ Simons, I Trapani - Human Gene Therapy, 2023 - liebertpub.com
Inherited forms of blindness and deafness are highly prevalent and severe conditions that
significantly impact the lives of millions of people worldwide. The lack of therapeutic options …

Multiscale photonic imaging of the native and implanted cochlea

D Keppeler, CA Kampshoff… - Proceedings of the …, 2021 - National Acad Sciences
The cochlea of our auditory system is an intricate structure deeply embedded in the temporal
bone. Compared with other sensory organs such as the eye, the cochlea has remained …