Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The ability of articular cartilage to repair itself is limited because it lacks blood vessels,
nerves, and lymph tissue. Once damaged, it can lead to joint swelling and pain, accelerating …

Osteoarthritis (OA) is characterized by cartilage degradation and subchondral bone
remodeling. However, most available studies focus on either cartilage degradation or …

Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly
secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) …

Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis
leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the …

Osteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that
affects the whole joint. The pathogenesis of OA is poorly understood and there is a lack of …

Nanomedicines with controlled drug release have received increasing attention as an
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …

Osteoarthritis (OA) is a common articular degenerative disease characterized by loss of
cartilage matrix and subchondral bone sclerosis. Kartogenin (KGN) has been reported to …

As the main load-bearing structure in the human body, bone and cartilage are susceptible to
damage in sports and other activities. The repair and regeneration of bone and articular …