Sepsis is aggravated by an inappropriate immune response to invading microorganisms,
which occasionally leads to multiple organ failure. Several lines of evidence suggest that the …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

Following its benchmark discovery, nitric oxide (NO) is now known to play important
functional roles in a variety of physiological systems. Within the vasculature, NO induces …

Cardiac function is controlled by the autonomic nervous system (ie, the sympathetic and the
parasympathetic nervous systems), which act via adrenoceptors and muscarinic …

Several ion channels are reportedly redox responsive, but the molecular basis for the
changes in activity is not known. The mechanism of nitric oxide action on the cardiac calcium …

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and
regulates cardiac function through both vascular-dependent and-independent effects. The …

Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic
acids with an interesting array of biological activities; eg, antioxidant, anti-inflammatory …

Expression of innate immune response proteins, including IL-1β, TNF, and the cytokine-
inducible isoform of nitric oxide synthase (iNOS), have been documented in the hearts of …

BACKGROUND: Restoration of blood supply to an organ after a critical period of ischemia
results in parenchymal injury and dysfunction of the organ referred to as reperfusion injury …

Beta1-and beta2-adrenoceptors in heart muscle cells mediate the catecholamine-induced
increase in the force and frequency of cardiac contraction. Recently, in addition, we …