[HTML][HTML] From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology

ZH Israili, WD Hall - Annals of internal medicine, 1992 - acpjournals.org
▪ Objective: To review available information on cough and angioneurotic edema associated
with angiotensin-converting enzyme (ACE) inhibitors.▪ Data Sources: All relevant articles …

[HTML][HTML] A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the …

RE Kast, JA Boockvar, A Brüning, F Cappello… - Oncotarget, 2013 - ncbi.nlm.nih.gov
To improve prognosis in recurrent glioblastoma we developed a treatment protocol based
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …

Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors

J Janke, S Engeli, K Gorzelniak, FC Luft… - Diabetes, 2002 - Am Diabetes Assoc
Recent studies suggest that angiotensin II (Ang II) plays a role in the adipogenesis of murine
preadipocytes. Here, we examined the role of Ang II for the differentiation of primary cultured …

Current state and future perspective of cardiovascular medicines derived from natural products

C Zhao, S Li, J Zhang, Y Huang, L Zhang… - Pharmacology & …, 2020 - Elsevier
The contribution of natural products (NPs) to cardiovascular medicine has been extensively
documented, and many have been used for centuries. Cardiovascular disease (CVD) is the …

Effect of angiotensin II on hematopoietic progenitor cell proliferation

KE Rodgers, S Xiong, R Steer, GS DiZerega - Stem cells, 2000 - academic.oup.com
Angiotensin II (AII) induced the proliferation of hematopoietic progenitor cells (HPC) isolated
from murine bone marrow or human cord blood. The formation of colonies with more than 50 …

[HTML][HTML] CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline …

RE Kast, G Karpel-Massler, ME Halatsch - Oncotarget, 2014 - ncbi.nlm.nih.gov
CUSP9 treatment protocol for recurrent glioblastoma was published one year ago. We now
present a slight modification, designated CUSP9*. CUSP9* drugs-aprepitant, artesunate …

[HTML][HTML] Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases

MF Rasool, S Ali, S Khalid, R Khalid, A Majeed… - Scientific Reports, 2021 - nature.com
The advancement in the processing speeds of computing machines has facilitated the
development of complex physiologically based pharmacokinetic (PBPK) models. These …

[HTML][HTML] Developing and scaling up captopril-loaded electrospun ethyl cellulose fibers for sustained-release floating drug delivery

Y Geng, GR Williams - International Journal of Pharmaceutics, 2023 - Elsevier
In this work ethyl cellulose (EC) was used as a matrix polymer and loaded with captopril,
with the goal to fabricate electrospun fibers as potential sustained-release floating gastro …

Gastrointestinal transit and systemic absorption of captopril from a pulsed-release formulation

IR Wilding, SS Davis, M Bakhshaee… - Pharmaceutical …, 1992 - Springer
Captopril has been administered to eight healthy male subjects by means of a pulsatile
delivery system that was designed to release the drug in the colonic region of the intestine …