3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate

J Nicolas, S Magli, L Rabbachin, S Sampaolesi… - …, 2020 - ACS Publications
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

New developments in medical applications of hybrid hydrogels containing natural polymers

C Vasile, D Pamfil, E Stoleru, M Baican - Molecules, 2020 - mdpi.com
New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by
combining natural polymers with synthetic ones, have been reviewed …

[PDF][PDF] Cross-linking in hydrogels-a review

J Maitra, VK Shukla - Am. J. Polym. Sci, 2014 - researchgate.net
Hydrogels represent a class of high water content polymers with physical or chemical
crosslinks. Their physical properties are similar to soft tissues. Cross linking is a stabilization …

Design properties of hydrogel tissue-engineering scaffolds

J Zhu, RE Marchant - Expert review of medical devices, 2011 - Taylor & Francis
This article summarizes the recent progress in the design and synthesis of hydrogels as
tissue-engineering scaffolds. Hydrogels are attractive scaffolding materials owing to their …

Additive manufacturing of biomaterials—Design principles and their implementation

MJ Mirzaali, V Moosabeiki, SM Rajaai, J Zhou… - Materials, 2022 - mdpi.com
Additive manufacturing (AM, also known as 3D printing) is an advanced manufacturing
technique that has enabled progress in the design and fabrication of customised or patient …

[HTML][HTML] Design and development of hybrid hydrogels for biomedical applications: Recent trends in anticancer drug delivery and tissue engineering

MH Cai, XY Chen, LQ Fu, WL Du, X Yang… - … in Bioengineering and …, 2021 - frontiersin.org
The applications of hydrogels in biomedical field has been since multiple decades.
Discoveries in biology and chemistry render this platform endowed with much engineering …

Regenerative therapies for central nervous system diseases: a biomaterials approach

RY Tam, T Fuehrmann, N Mitrousis… - …, 2014 - nature.com
The central nervous system (CNS) has a limited capacity to spontaneously regenerate
following traumatic injury or disease, requiring innovative strategies to promote tissue and …

Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment

LH Nguyen, M Gao, J Lin, W Wu, J Wang, SY Chew - Scientific reports, 2017 - nature.com
Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in
axon regeneration. Unfortunately, currently established treatments, such as direct drug …

Hydrogels and cell based therapies in spinal cord injury regeneration

RC Assunção-Silva, ED Gomes, N Sousa… - Stem cells …, 2015 - Wiley Online Library
Spinal cord injury (SCI) is a central nervous system‐(CNS‐) related disorder for which there
is yet no successful treatment. Within the past several years, cell‐based therapies have …

[HTML][HTML] Mesenchymal stem cells in treatment of spinal cord injury and amyotrophic lateral sclerosis

E Sykova, D Cizkova, S Kubinova - Frontiers in cell and …, 2021 - frontiersin.org
Preclinical and clinical studies with various stem cells, their secretomes, and extracellular
vesicles (EVs) indicate their use as a promising strategy for the treatment of various …