Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of
morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic …

The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …

The purpose of this statement is to describe and define the phenotypic abnormalities that
can be identified on visual and quantitative evaluation of computed tomographic (CT) …

Importance Airflow obstruction on spirometry is universally used to define chronic obstructive
pulmonary disease (COPD), and current or former smokers without airflow obstruction may …

Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre
observational study of chronic obstructive pulmonary disease (COPD) designed to guide …

Rationale: Increasing awareness of the prevalence and significance of Preserved Ratio
Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for …

Background There is limited data on the risk factors and phenotypical characteristics
associated with spirometrically confirmed COPD in never-smokers in the general population …

Background Pattern of emphysema at chest CT, scored visually by using the Fleischner
Society system, is associated with physiologic impairment and mortality risk. Purpose To …

Purpose To determine whether visually assessed patterns of emphysema at CT might
provide a simple assessment of mortality risk among cigarette smokers. Materials and …

Background Pulmonary emphysema is divided into 3 major subtypes at autopsy:
centrilobular, paraseptal, and panlobular emphysema. These subtypes can be defined by …