Application of molecularly imprinted polymers as artificial receptors for imaging

T Vaneckova, J Bezdekova, G Han, V Adam… - Acta Biomaterialia, 2020 - Elsevier
Medical diagnostics aims at specific localization of molecular targets as well as detection of
abnormalities associated with numerous diseases. Molecularly imprinted polymers (MIPs) …

Multiphoton microscopy in surgical oncology-a systematic review and guide for clinical translatability

TT König, J Goedeke, OJ Muensterer - Surgical Oncology, 2019 - Elsevier
Background Multiphoton microscopy (MPM) facilitates three-dimensional, high-resolution
functional imaging of unlabeled tissues in vivo and ex vivo. This systematic review discusses …

Polarization-resolved second-harmonic generation imaging through a multimode fiber

A Cifuentes, T Pikálek, P Ondráčková… - Optica, 2021 - opg.optica.org
Multimode fiber-based endoscopes have recently emerged as a tool for minimally invasive
endoscopy in tissue, at depths well beyond the reach of multiphoton imaging. Here, we …

Optical signatures derived from deep UV to NIR excitation discriminates healthy samples from low and high grades glioma

H Mehidine, A Chalumeau, F Poulon, F Jamme… - Scientific Reports, 2019 - nature.com
Among all the tumors of the central nervous system (CNS), glioma are the most deadly and
the most malignant. Surgical resection is the standard therapeutic method to treat this type of …

Two-photon microendoscope for label-free imaging in stereotactic neurosurgery

TA Welton, NM George, BN Ozbay… - Biomedical Optics …, 2023 - opg.optica.org
We demonstrate a gradient refractive index (GRIN) microendoscope with an outer diameter
of∼ 1.2 mm and a length of∼ 186 mm that can fit into a stereotactic surgical cannula. Two …

Molecular changes tracking through multiscale fluorescence microscopy differentiate Meningioma grades and non-tumoral brain tissues

H Mehidine, M Refregiers, F Jamme, P Varlet… - Scientific Reports, 2021 - nature.com
Meningioma is the most common primary intracranial extra-axial tumor. Total surgical
removal is the standard therapeutic method to treat this type of brain tumors. However, the …

Miniature fluorescence sensor for quantitative detection of brain tumour

JP Ndabakuranye, J Belcourt, D Sharma… - Lab on a Chip, 2024 - pubs.rsc.org
Fluorescence-guided surgery has emerged as a vital tool for tumour resection procedures.
As well as intraoperative tumour visualisation, 5-ALA-induced PpIX provides an avenue for …

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

A Gautheron, JD Bernstock, T Picart… - Frontiers in …, 2024 - frontiersin.org
The review begins with an overview of the fundamental principles/physics underlying light,
fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5 …

Quantitative and qualitative analysis of pulmonary arterial hypertension fibrosis using wide-field second harmonic generation microscopy

Y Padrez, L Golubewa, T Kulahava, T Vladimirskaja… - Scientific reports, 2022 - nature.com
We demonstrated that wide-field second harmonic generation (SHG) microscopy of lung
tissue in combination with quantitative analysis of SHG images is a powerful tool for fast and …

Maximizing the extent of resection in high-grade glioma

G Grasso, F Torregrossa, L Leone - World Neurosurgery, 2019 - iris.unipa.it
High-grade gliomas (HGGs) are devastating tumors associated with one of the worst
prognoses in oncology. Glioblastoma multiforme (GBM) is the most frequently reported …