Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems
T Romeo, CA Vakulskas… - Environmental …, 2013 - Wiley Online Library
Originally described as a repressor of gene expression in the stationary phase of growth,
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …
RNAs: regulators of bacterial virulence
J Gripenland, S Netterling, E Loh, T Tiensuu… - Nature Reviews …, 2010 - nature.com
RNA-based pathways that regulate protein expression are much more widespread than
previously thought. Regulatory RNAs, including 5′ and 3′ untranslated regions next to the …
previously thought. Regulatory RNAs, including 5′ and 3′ untranslated regions next to the …
In vivo cleavage map illuminates the central role of RNase E in coding and non-coding RNA pathways
Understanding RNA processing and turnover requires knowledge of cleavages by major
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating …
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating …
Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics
CsrA is a post-transcriptional regulatory protein that is widely distributed among bacteria.
This protein influences bacterial lifestyle decisions by binding to the 5′ untranslated and/or …
This protein influences bacterial lifestyle decisions by binding to the 5′ untranslated and/or …
Environmental fate of double-stranded RNA in agricultural soils
S Dubelman, J Fischer, F Zapata, K Huizinga, C Jiang… - PloS one, 2014 - journals.plos.org
A laboratory soil degradation study was conducted to determine the biodegradation
potential of a DvSnf7 dsRNA transcript derived from a Monsanto genetically modified (GM) …
potential of a DvSnf7 dsRNA transcript derived from a Monsanto genetically modified (GM) …
Programmable control of bacterial gene expression with the combined CRISPR and antisense RNA system
YJ Lee, A Hoynes-O'Connor, MC Leong… - Nucleic acids …, 2016 - academic.oup.com
A central goal of synthetic biology is to implement diverse cellular functions by predictably
controlling gene expression. Though research has focused more on protein regulators than …
controlling gene expression. Though research has focused more on protein regulators than …
CsrA activates flhDC expression by protecting flhDC mRNA from RNase E‐mediated cleavage
AV Yakhnin, CS Baker, CA Vakulskas… - Molecular …, 2013 - Wiley Online Library
Csr is a conserved global regulatory system that controls expression of several hundred E
scherichia coli genes. CsrA protein represses translation of numerous genes by binding to …
scherichia coli genes. CsrA protein represses translation of numerous genes by binding to …
RNA-binding proteins driving the regulatory activity of small non-coding RNAs in bacteria
Small non-coding RNAs (sRNAs) are critical post-transcriptional regulators of gene
expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and …
expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and …
Regulation of mRNA stability during bacterial stress responses
DA Vargas-Blanco, SS Shell - Frontiers in microbiology, 2020 - frontiersin.org
Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their
transcriptional and posttranscriptional machinery as a response. Under conditions that …
transcriptional and posttranscriptional machinery as a response. Under conditions that …
New targets for drug design: importance of nsp14/nsp10 complex formation for the 3'‐5'exoribonucleolytic activity on SARS‐CoV‐2
M Saramago, C Bárria, VG Costa, CS Souza… - The FEBS …, 2021 - Wiley Online Library
SARS‐CoV‐2 virus has triggered a global pandemic with devastating consequences. The
understanding of fundamental aspects of this virus is of extreme importance. In this work, we …
understanding of fundamental aspects of this virus is of extreme importance. In this work, we …