Background Only some individuals who use drugs recreationally eventually develop a
substance use disorder, characterized in part by the rigid engagement in drug foraging …

Despite the prevalence of drug use within society, only a subset of individuals actively taking
addictive drugs lose control over their intake and develop compulsive drug-seeking and …

Objective Motivational deficits are prevalent in patients with schizophrenia, persist despite
antipsychotic treatment, and predict long‐term outcomes. Evidence suggests that patients …

Impulsivity is considered a vulnerability trait for addiction. Recently, we found trait non‐
planning impulsiveness measured with the Karolinska Scales of Personality was negatively …

The thalamus and central dopamine signaling have been shown to play important roles in
high-level cognitive processes including impulsivity. However, little is known about the role …

Impulsive action can be measured using rat's responses on a differential reinforcement of
low-rate-response (DRL) task in which performance may be varied between rats …

Only some individuals using drugs recreationally eventually become addicted, and persist in
drug seeking and taking despite adverse consequences. The neurobehavioral determinants …

Highlights•Development of drug seeking habits depends upon intrastriatal functional shifts.•
Endocannabinoid, opioid and adenosinergic systems control striatal plasticity.•These …

Substance abuse disorder is a chronically relapsing disease that is characterized in part by
compulsion to seek and take drug in the presence of adverse consequences and in …

Mechanisms underlying affective and cognitive deficits in Parkinson's disease (PD) remain
less studied than motor symptoms. Nucleus accumbens (NAc) is affected in PD and due to …