The use of oral contraceptives (OC) is a well established risk factor for venous thrombosis. It
has been known for many years that almost all haemostatic parameters ie plasma levels of …

Arterial and venous thromboses, with their clinical manifestations such as stroke, myocardial
infarction (MI), or pulmonary embolism, are the major causes of death in developed …

Abstract Factor V G1691A (FV‐Leiden) and prothrombin G20210A mutations are major
inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations …

Aims The interaction between the R506Q mutation of factor V and the G20210A mutation of
prothrombin with oral contraceptives on venous thromboembolism was evaluated. Methods …

Thromboembolic disease in children has become more frequent over the last decade. This
includes venous and arterial thrombosis that is within and outside of the central nervous …

Recently, a single mutation in the 3'-un of region of the prothrombin gene was reported,
resulting in a G-to-A substitution. This finding added to the growing list of genetic disorders …

Background Unrecognized thrombophilic defects increase the risk of venous
thromboembolism (VTE) in women during oral contraception (OC). We evaluated the …

Resistance to activated protein C (APC) degradation caused by a specific point mutation in
the factor V (FV) gene, FV: R506Q or FV‐Leiden, which replaces Arg506 with Gln at the APC …

There is a rapidly growing body of evidence linking genetic polymorphisms with functional
changes in proteins that are responsible for the metabolism and disposition of many …

The possibility of life threatening venous thromboembolism (VTE) associated with long-haul
air travel has received increasing attention in recent years. VTE can develop after long travel …