Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - … and Targeted Therapy, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

[HTML][HTML] Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair

J Li, W Luo, C Xiao, J Zhao, C Xiang, W Liu, R Gu - Theranostics, 2023 - ncbi.nlm.nih.gov
Traumatic spinal cord injury (SCI) can cause severe neurological impairments. Clinically
available treatments are quite limited, with unsatisfactory remediation effects. Residing …

Triboelectric nanogenerators stimulated electroacupuncture (EA) treatment for promoting the functional recovery after spinal cord injury

X Wei, Y Wang, B Tan, E Zhang, B Wang, H Su, L Yu… - Materials Today, 2022 - Elsevier
Electroacupuncture (EA), as a particular type of electrostimulation treatment, has an
extensive application in the field of biomedicine. Triboelectric nanogenerator (TENG) has …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Metformin improves functional outcomes, activates neural precursor cells, and modulates microglia in a sex-dependent manner after spinal cord injury

EAB Gilbert, J Livingston… - Stem Cells …, 2023 - academic.oup.com
Spinal cord injury (SCI) results in devastating patient outcomes with few treatment options. A
promising approach to improve outcomes following SCI involves the activation of …

[HTML][HTML] Proper wiring of newborn neurons to control bladder function after complete spinal cord injury

F Hao, F Jia, P Hao, H Duan, Z Wang, Y Fan, W Zhao… - Biomaterials, 2023 - Elsevier
Activation of endogenous neurogenesis by bioactive materials enables restoration of
sensory/motor function after complete spinal cord injury (SCI) via formation of new relay …

Bibliometric analysis of stem cells for spinal cord injury: current status and emerging frontiers

Z Shang, P Wanyan, M Wang, B Zhang, X Cui… - Frontiers in …, 2023 - frontiersin.org
Background: This study aimed to conduct a bibliometric analysis of the literature on stem cell
therapy for spinal cord injury to visualize the research status, identify hotspots, and explore …

[HTML][HTML] Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

R Yang, J Pan, Y Wang, P Xia, M Tai… - Frontiers in Cellular …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After
SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes …

IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury

J Wang, L Xu, D Peng, Y Zhu, Z Gu, Y Yao, H Li… - Inflammation and …, 2023 - Springer
Background Spinal cord injury (SCI) causes nearly all patients to suffer from protracted
disabilities. An emerging therapeutic strategy involving the recruitment of endogenous …

UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury

L Ding, W Chu, Y Xia, M Shi, T Li, FQ Zhou… - Cell Death & …, 2023 - nature.com
Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult
neurogenesis; however, it is extremely limited in the spinal cord after injury. Recent …