Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After
SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes …

Central nervous system (CNS) diseases are a leading cause of death and disability. Due to
CNS neurons have no self-renewal and regenerative ability as they mature, their loss after …

Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult
neurogenesis; however, it is extremely limited in the spinal cord after injury. Recent …

Current therapeutic strategies for spinal cord injury (SCI) cannot fully facilitate neural
regeneration or improve function. Arginine decarboxylase (ADC) synthesizes agmatine, an …

Spinal cord injury (SCI) causes neuroinflammation, neuronal death, and severe axonal
connections. Alleviating neuroinflammation, protecting residual cells and promoting …

Spinal cord injury (SCI) remains a formidable challenge, lacking effective treatments.
Following SCI, neural stem cells (NSCs) migrate to SCI sites, offering a potential avenue for …

Astrocytes are the most abundant and widespread glial cells in the central nervous system.
The heterogeneity of astrocytes plays an essential role in spinal cord injury (SCI) repair …

Background Vascular endothelial cells are pivotal in the pathophysiological progression
following spinal cord injury (SCI). The UTX (Ubiquitously Transcribed Tetratripeptide Repeat …

Mature neurons in the human central nervous system (CNS) fail to regenerate after injuries.
This is a common denominator across different aetiologies, including multiple sclerosis …

Ependymal cells lining the central canal of the spinal cord play a crucial role in providing a
physical barrier and in the circulation of cerebrospinal fluid. These cells express the FOXJ1 …