The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …

To reconstruct modern human evolutionary history and identify loci that have shaped hunter-
gatherer adaptation, we sequenced the whole genomes of five individuals in each of three …

Incidence and prevalence of hypopituitarism are estimated to be 4· 2 per 100 000 per year
and 45· 5 per 100 000, respectively. Although the clinical symptoms of this disorder are …

The transcription factor SOX2 is expressed most notably in the developing CNS and
placodes, where it plays critical roles in embryogenesis. Heterozygous de novo mutations in …

Objective: The objective is to provide guidelines for the evaluation and treatment of adults
with GH deficiency (GHD). Participants: The chair of the Task Force was selected by the …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis.
The development of the pituitary gland depends on the sequential temporal and spatial …

Context: Mutations in transcription factors result in combined pituitary hormone deficiency
(CPHD). Objective: A genetic screening strategy, based on endocrine and neuroradiological …

Context Familial short stature (FSS) is a term describing a growth disorder that is vertically
transmitted. Milder forms may result from the combined effect of multiple genes; more severe …

Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic
and developmental studies. Our understanding of the physiological consequences of altered …