[HTML][HTML] Antimicrobial peptides for combating drug-resistant bacterial infections

J Xuan, W Feng, J Wang, R Wang, B Zhang, L Bo… - Drug Resistance …, 2023 - Elsevier
The problem of drug resistance due to long-term use of antibiotics has been a concern for
years. As this problem grows worse, infections caused by multiple bacteria are expanding …

[HTML][HTML] Antimicrobial peptides—Mechanisms of action, antimicrobial effects and clinical applications

J Talapko, T Meštrović, M Juzbašić, M Tomas, S Erić… - Antibiotics, 2022 - mdpi.com
The growing emergence of antimicrobial resistance represents a global problem that not
only influences healthcare systems but also has grave implications for political and …

[HTML][HTML] Insect-pathogen crosstalk and the cellular-molecular mechanisms of insect immunity: uncovering the underlying signaling pathways and immune regulatory …

DK Mahanta, TK Bhoi, J Komal, I Samal… - Frontiers in …, 2023 - frontiersin.org
Multicellular organisms are constantly subjected to pathogens that might be harmful.
Although insects lack an adaptive immune system, they possess highly effective anti …

Plant antimicrobial peptides: a comprehensive review of their classification, production, mode of action, functions, applications, and challenges

F Zou, C Tan, TS Shinali, B Zhang, L Zhang, Z Han… - Food & Function, 2023 - pubs.rsc.org
The emergence of pathogens resistant to conventional antibiotics and the growing interest in
developing alternative natural antimicrobial agents have prompted a search for plant …

SiameseCPP: a sequence-based Siamese network to predict cell-penetrating peptides by contrastive learning

X Zhang, L Wei, X Ye, K Zhang, S Teng… - Briefings in …, 2023 - academic.oup.com
Abstract Background Cell-penetrating peptides (CPPs) have received considerable attention
as a means of transporting pharmacologically active molecules into living cells without …

CycPeptMP: enhancing membrane permeability prediction of cyclic peptides with multi-level molecular features and data augmentation

J Li, K Yanagisawa, Y Akiyama - Briefings in Bioinformatics, 2024 - academic.oup.com
Cyclic peptides are versatile therapeutic agents that boast high binding affinity, minimal
toxicity, and the potential to engage challenging protein targets. However, the …

[HTML][HTML] Design of antimicrobial peptides with cell-selective activity and membrane-acting mechanism against drug-resistant bacteria

SC Park, H Son, YM Kim, JK Lee, S Park, HS Lim… - Antibiotics, 2022 - mdpi.com
Antimicrobial peptides (AMPs) can combat drug-resistant bacteria with their unique
membrane-disruptive mechanisms. This study aimed to investigate the antibacterial effects …

The synergistic effect of using bacteriophages and chitosan nanoparticles against pathogenic bacteria as a novel therapeutic approach

AS Abdelsattar, AY Yakoup, A Safwat… - International Journal of …, 2023 - Elsevier
Public health and environmental security are seriously at risk due to the growing
contamination of pathogenic microorganisms. Therefore, effective antimicrobials are …

Exploring the mechanism of photosensitizer conjugation on membrane perturbation of antimicrobial peptide: A multiscale molecular simulation study

Y Liu, M Song, J Wu, S Xie, Y Zhou, L Liu… - International Journal of …, 2023 - Elsevier
Antimicrobial peptides (AMPs) exert their biological functions by perturbation with cellular
membrane. Conjugation of AMPs with photosensitizer (PS) is a promising strategy for …

A comprehensive assessment and comparison of tools for HLA class I peptide-binding prediction

M Wang, L Kurgan, M Li - Briefings in Bioinformatics, 2023 - academic.oup.com
Human leukocyte antigen class I (HLA-I) molecules bind intracellular peptides produced by
protein hydrolysis and present them to the T cells for immune recognition and response …