▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Caveolae are a highly abundant but enigmatic feature of mammalian cells. They form
remarkably stable membrane domains at the plasma membrane but can also function as …

Caveolae are plasma membrane invaginations that may play an important role in numerous
cellular processes including transport, signaling, and tumor suppression. By targeted …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are
known primarily for their ability to transport molecules across endothelial cells, but modern …

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

Caveolae are small, bulb-shaped plasma membrane invaginations. Mutations that ablate
caveolae lead to diverse phenotypes in mice and humans, making it challenging to uncover …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a …

Integrin receptor binding to extracellular matrix proteins generates intracellular signals via
enhanced tyrosine phosphorylation events that are important for cell growth, survival, and …