The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined
by the Union for International Cancer Control (UICC) and American Joint Committee on …

The mismatch repair (MMR) system which detects and corrects base mismatches and
insertions and deletions that occur during DNA synthesis is deregulated in approximately …

Background: The prognostic value of BRAF and KRAS mutations within microsatellite-
unstable (MSI) and microsatellite-stable (MSS) subgroups of resected colon carcinoma …

Background/Aim: About 15-20% of colorectal cancers (CRCs) have deficiency in a mismatch
repair (MMR) protein. MMR has a high level of microsatellite instability (MSI-H). We have …

Simple Summary Patients with colorectal cancer without distant metastases are often cured
by surgical tumor resection. Follow-up is needed because of the risk of disease recurrence …

Mutations in KRAS are among the most frequent aberrations in cancer, including colon
cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule …

Simple Summary The poor prognosis outcome of patients with KRAS mutations (KRAS mut)
was correlated with an immunosuppressive tumor microenvironment (TME). At the gene …

The use of circulating tumor DNA (ctDNA) as a novel and non-invasive test for the diagnosis
and surveillance of cancer is a rapidly growing area of interest, with sequencing of ctDNA …

Kirsten rats sarcoma viral oncogene (KRAS), the first discovered human oncogene, has long
been recognized as “undruggable”. KRAS mutations frequently occur in multiple human …

Colorectal cancer has been ranked the third and second most prevalent of all cancers in
men and women, respectively, and it represents the fourth most common cause of cancer …