Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a
global level during the last decades and represent an everyday challenge, especially for the …

Introduction Antimicrobial resistance is a major threat to modern healthcare, and it is often
regarded that the antibiotic pipeline is 'dry.'Areas covered Antimicrobial agents active …

Objective This study evaluated the pharmacokinetic (PK) characteristics of benapenem in
subjects with mild to moderate renal impairment to provide a reference for benapenem …

Objective: Cefoperazone/sulbactam is a commonly used antibiotic combination against the
extended-spectrum beta-lactamases (ESBLs)-producing bacteria. The objective of this study …

Antibacterial resistance is a global health threat that requires further concrete action on the
part of all countries. In this context, one of the biggest concerns is whether enough new …

Introdução: A resistência antimicrobiana é a capacidade de um microrganismo impedir que
um agente antimicrobiano funcione contra ele, impondo sérias limitações no tratamento de …

As doenças infeciosas de etiologia bacteriana foram sempre um grave problema para a
sociedade, não só pela sua fácil e rápida propagação, como pela elevada mortalidade e …

Penicillins, cephalosporins, carbapenems, and mono bactams are all βlactam antibiotics
and have a similar βlactam ring (Fig. 1) and mechanism of action (ie, inhibition of the …