Simple Summary Despite clinical success, only a limited percentage of cancer patients are
responsive to immunotherapy. Recently, gut microbiota modulation has been suggested as …

Mounting evidence suggests that the gut microbiota plays a crucial role in the development
and treatment of various cancers. Recent research on the urinary microbiota challenges the …

Background & Aims The prevalence of non-alcoholic steatohepatitis (NASH)-driven
hepatocellular carcinoma (HCC) is rising rapidly, yet its underlying mechanisms remain …

Nutritional factors play crucial roles in immune responses. The tumor-caused nutritional
deficiencies are known to affect antitumor immunity. Here, we demonstrate that pancreatic …

Oxygen is critical for all metazoan organisms on the earth and impacts various biological
processes in physiological and pathological conditions. While oxygen-sensing systems …

Vitamin B6 is a water-soluble vitamin which possesses antioxidant properties. Its
catalytically active form, pyridoxal 5'-phosphate (PLP), is a crucial cofactor for DNA and …

It has been proven that vitamins play an essential role in preventing certain diseases since
ancient times. It is thus fruitless to approach the roles of vitamins without making reference to …

T cells must adapt to variations in tissue microenvironments; these adaptations include the
degree of oxygen availability. The hypoxia-inducible factor (HIF) transcription factors control …

Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with
compromised immune function in affected patients. This can be attributed to the secretion of …

Oxygen is critical for all metazoan organisms on the earth and impacts various biological
processes in physiological and pathological conditions. While oxygen sensing systems …