Background Bladder cancer is the sixth most common cancer in the world and the incidence
is particularly high in southwestern Taiwan. Previous studies have identified several tumor …

Results: The most important epigenetic changes include DNA methylation, histone
modification and microRNA regulation. Both DNA hypomethylation and hypermethylation …

Cystic fibrosis (CF) is an autosomal recessive disease which involves the mutations in the
cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF involves in the …

Bladder cancer like other cancers arises from the accumulation of many genetic and
epigenetic changes that lead to the activation of proto-oncogenes or inactivation of tumor …

OBJECTIVES: Urinary hypermethylation of BCL2, hTERT, and DAPK promoters has been
previously demonstrated as an accurate biomarker for the detection of urothelial carcinoma …

Identifying biomarkers in body fluids may improve the noninvasive detection of colorectal
cancer. Previously, we identified N-Myc downstream-regulated gene 4 (NDRG4) and GATA …

Urothelial bladder cancer is a complex disease displaying a landscape of heterogenous
molecular subtypes, mutation profiles and clinical presentations. Diagnosis and surveillance …

The cystic fibrosis transmembrane conductance regulator (CFTR) holds an important role in
retaining lung function, but its association with lung cancer is unclear. A case-control study …

Deregulation of promyelocytic leukemia zinc finger protein (PLZF), a tumor suppressor gene,
was reported in different types of solid tumors. This study for the first time explored the …

OBJECTIVE (S): The poor prognosis associated with ovarian cancer is due to the lack of
overt early symptoms and the absence of reliable diagnostic screening methods. Since …