Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

The dendritic tree and brain disorders

VA Kulkarni, BL Firestein - Molecular and Cellular Neuroscience, 2012 - Elsevier
Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendrite arbors, and dendritic …

Widespread RNA editing dysregulation in brains from autistic individuals

SS Tran, HI Jun, JH Bahn, A Azghadi… - Nature …, 2019 - nature.com
Transcriptomic analyses of postmortem brains have begun to elucidate molecular
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …

[HTML][HTML] Using whole-exome sequencing to identify inherited causes of autism

WY Timothy, MH Chahrour, ME Coulter, S Jiralerspong… - Neuron, 2013 - cell.com
Despite significant heritability of autism spectrum disorders (ASDs), their extreme genetic
heterogeneity has proven challenging for gene discovery. Studies of primarily simplex …

Autism genetics

AM Persico, V Napolioni - Behavioural brain research, 2013 - Elsevier
Autism spectrum disorder (ASD) is a severe neuropsychiatric disease with strong genetic
underpinnings. However, genetic contributions to autism are extremely heterogeneous, with …

Circuit level defects in the developing neocortex of Fragile X mice

JT Gonçalves, JE Anstey, P Golshani… - Nature …, 2013 - nature.com
Subtle alterations in how cortical network dynamics are modulated by different behavioral
states could disrupt normal brain function and underlie symptoms of neuropsychiatric …

[HTML][HTML] Heterogeneity within autism spectrum disorders: what have we learned from neuroimaging studies?

RK Lenroot, PK Yeung - Frontiers in human neuroscience, 2013 - frontiersin.org
Autism spectrum disorders (ASD) display significant heterogeneity. Although most
neuroimaging studies in ASD have been designed to identify commonalities among affected …

Translational animal models of autism and neurodevelopmental disorders

JN Crawley - Dialogues in clinical neuroscience, 2012 - Taylor & Francis
Autism is a neurodevelopmental disorder whose diagnosis is based on three behavioral
criteria: unusual reciprocal social interactions, deficits in communication, and stereotyped …

[HTML][HTML] GABAB receptor agonist R-baclofen reverses social deficits and reduces repetitive behavior in two mouse models of autism

JL Silverman, MC Pride, JE Hayes… - …, 2015 - nature.com
Autism spectrum disorder (ASD) is diagnosed by two core behavioral criteria, unusual
reciprocal social interactions and communication, and stereotyped, repetitive behaviors with …

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

K Griesi-Oliveira, A Acab, AR Gupta, DY Sunaga… - Molecular …, 2015 - nature.com
An increasing number of genetic variants have been implicated in autism spectrum
disorders (ASDs), and the functional study of such variants will be critical for the elucidation …