Immune and inflammatory mechanisms of abdominal aortic aneurysm

AC Marquez-Sanchez, EK Koltsova - Frontiers in immunology, 2022 - frontiersin.org
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …

AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Recent advances in targeted therapy for inflammatory vascular diseases

K Zhao, Z Zeng, Y He, R Zhao, J Niu, H Sun, S Li… - Journal of Controlled …, 2024 - Elsevier
Vascular diseases constitute a significant contributor to worldwide mortality rates, placing a
substantial strain on healthcare systems and socio-economic aspects. They are closely …

Pathogenesis-guided rational engineering of nanotherapies for the targeted treatment of abdominal aortic aneurysm by inhibiting neutrophilic inflammation

K Hu, L Zhong, W Lin, G Zhao, W Pu, Z Feng, M Zhou… - ACS …, 2024 - ACS Publications
Abdominal aortic aneurysm (AAA) remains a fatal disease in the elderly. Currently, no drugs
can be clinically used for AAA therapy. Considering the pivotal role of neutrophils in the …

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology

D Domagała, K Data, H Szyller, M Farzaneh… - Cells, 2024 - mdpi.com
A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm,
which is characterized by a significant bulge on the vessel surface that may have …

Toll-like receptors as pro-thrombotic drivers in viral infections: a narrative review

B Panzer, CW Kopp, C Neumayer, R Koppensteiner… - Cells, 2023 - mdpi.com
Toll-like receptors (TLRs) have a critical role in the pathogenesis and disease course of viral
infections. The induced pro-inflammatory responses result in the disturbance of the …

[HTML][HTML] PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm

Y Xiong, S Liu, Y Liu, J Zhao, J Sun, Y Li, B Pan… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) is one of the most life-threatening cardiovascular
diseases; however, effective drug treatments are still lacking. The formation of neutrophil …

Reducing abdominal aortic aneurysm progression by blocking neutrophil extracellular traps depends on thrombus formation

N Ibrahim, S Bleichert, J Klopf, G Kurzreiter… - Basic to Translational …, 2024 - jacc.org
Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of abdominal aortic
aneurysm (AAA), located in adventitia and intraluminal thrombus. We compared the …

Micro-and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches

M Poledniczek, C Neumayer, CW Kopp, O Schlager… - Biomedicines, 2023 - mdpi.com
Inflammation has a critical role in the development and progression of atherosclerosis. On
the molecular level, inflammatory pathways negatively impact endothelial barrier properties …

The deubiquitinase otud1 suppresses secretory neutrophil polarization and ameliorates immunopathology of periodontitis

J Song, Y Zhang, Y Bai, X Sun, Y Lu, Y Guo… - Advanced …, 2023 - Wiley Online Library
Tissue‐infiltrating neutrophils (TINs) secrete various signaling molecules to establish
paracrine communication within the inflammatory milieu. It is imperative to identify molecular …