Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Hypercholesterolaemia is a risk factor for the development of atherosclerotic disease.
Atorvastatin lowers plasma low-density lipoprotein (LDL) cholesterol levels by inhibition of …

We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system
under continuous flow conditions in a serum-free defined medium utilizing a pumpless …

Background Statins reduce the incidence of cardiovascular events in persons with type 2
diabetes mellitus. However, the benefit of statins in such patients receiving hemodialysis …

Endogenous mechanisms leading to host protection and resolution of infections without
immunosuppression are of wide interest,. Here we elucidate the structures of four new host …

The hepatic organic anion transporting polypeptides (OATPs) influence the
pharmacokinetics of several drug classes and are involved in many clinical drug–drug …

Background—The role of statins in the prevention of contrast-induced acute kidney injury
(CIAKI) is controversial. Methods and Results—First, we investigated the in vivo effects of …

Background and objectives: Data suggest that atorvastatin may be nephroprotective. This
subanalysis of the Treating to New Targets study investigated how intensive lipid lowering …

Background People with advanced kidney disease treated with dialysis experience mortality
rates from cardiovascular disease that are substantially higher than for the general …

The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …