Chronic rhinosinusitis (CRS) is a diverse chronic inflammatory disease of the sinonasal
mucosa. CRS manifests itself in a variety of clinical and immunologic patterns. The …

Chronic rhinosinusitis (CRS) is one of the most frequent comorbidities associated with
asthma and it contributes to an amplified global disease burden in asthmatics. CRS …

Background Dupilumab, a mAb targeting IL-4Rα, improves upper and lower airway
symptoms in patients with aspirin-exacerbated respiratory disease (AERD), but the …

Background Basic studies suggest that severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection can affect chronic rhinosinusitis (CRS), but there is unclear real …

Purpose This study investigated the clinical implications of neutrophil extracellular trap
(NET) formation (NETosis) and eosinophil extracellular trap (EET) formation (EETosis) …

Introduction: The emergency of biologics and surgical techniques targeting the specific
inflammatory endotype in chronic rhinosinusitis with nasal polyps (CRSwNP) asks for …

Introduction Asthma comorbidities are a frequent cause of adverse outcomes, such as poor
asthma control, frequent asthma attacks, reduced quality of life, and higher healthcare costs …

Objective To provide a comprehensive state-of-the-art review of the emerging role of urine
leukotriene E4 (uLTE4) as a biomarker in the diagnosis of chronic rhinosinusitis (CRS) …

Background Middle turbinectomy (MT) has always been controversial. MT significantly alters
the anatomy and redistributes the inhaled air. The current study is designed to quantify the …

Aims Benralizumab, a humanized, afucosylated monoclonal antibody against the interleukin
5 receptor, α subunit, causes rapid depletion of eosinophils by antibody‐dependent cellular …