Triterpenoids as reactive oxygen species modulators of cell fate

T Ling, L Boyd, F Rivas - Chemical Research in Toxicology, 2022 - ACS Publications
The triterpenoid natural products have played an important role in understanding
mechanistic models of human diseases. These natural products are diverse, but many have …

[HTML][HTML] Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade

ADR Nurcahyanti, A Jap, J Lady, D Prismawan… - Biomedicine & …, 2021 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million
people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several …

Chemistry and Pharmacological Activity of Sesquiterpenoids from the Chrysanthemum Genus

S Jiang, M Wang, Z Jiang, S Zafar, Q Xie, Y Yang, Y Liu… - Molecules, 2021 - mdpi.com
Plants from the Chrysanthemum genus are rich sources of chemical diversity and, in recent
years, have been the focus of research on natural products chemistry. Sesquiterpenoids are …

Induction of apoptosis by isoalantolactone in human hepatocellular carcinoma Hep3B cells through activation of the ROS-dependent JNK signaling pathway

MY Kim, H Lee, SY Ji, SY Kim, H Hwangbo, SH Park… - Pharmaceutics, 2021 - mdpi.com
Isoalantolactone (IALT) is one of the isomeric sesquiterpene lactones isolated from the roots
of Inula helenium L. IALT is known to possess various biological and pharmacological …

1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway

B Yu, XQ Jin, WY Yu, YY Dong, HZ Ying… - International …, 2021 - Elsevier
Inulae Flos was widely distributed throughout Europe, Africa, and Asia, and was commonly
used as a folk medicine in clinic for treating various respiratory diseases, including cough …

[HTML][HTML] Ethnopharmacological and phytochemical attributes of Indian Tinospora species: A comprehensive review

B Singh, S Nathawat, RA Sharma - Arabian Journal of Chemistry, 2021 - Elsevier
Total 34 species of Tinospora genus are found in Africa, Australia, Asia, Madagascar and
Pacific regions of the World. Nine species of Tinospora are naturalized in the different states …

Anticancer targets and signaling pathways activated by britannin and related pseudoguaianolide sesquiterpene lactones

C Bailly - Biomedicines, 2021 - mdpi.com
Sesquiterpene lactones (SLs) are abundant in plants and display a large spectrum of
bioactivities. The compound britannin (BRT), found in different Inula species, is a …

Evaluation of Activity of Sesquiterpene Lactones and Chicory Extracts as Acetylcholinesterase Inhibitors Assayed in Calorimetric and Docking Simulation Studies

A Jaśkiewicz, G Budryn, M Carmena-Bargueño… - Nutrients, 2022 - mdpi.com
The aim of the study was to explain the effects of sesquiterpene lactones (SLs) from chicory
(Cichorium intybus L.) root extracts as inhibitors of acetylcholinesterase (AChE) at the …

Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth …

M Alissa, A Hjazi, GS Abusalim, GS Aloraini… - Frontiers in …, 2024 - frontiersin.org
Introduction: Essential oil‒based nanoemulsions (NEs) are the subjects of extensive
investigation due to their potential to address a variety of oral health issues. NEs are delivery …

[PDF][PDF] In silico analysis of potential antidiabetic phytochemicals from Matricaria chamomilla L. against ptp1b and aldose reductase for type 2 diabetes mellitus and its …

AS Hariftyani, LA Kurniawati… - Natural Product …, 2021 - researchgate.net
Abstract Type 2 diabetes mellitus (T2DM) and its complications are important
noncommunicable diseases with high mortality rates. Protein tyrosine phosphatase 1B …