Advances in the natural α‐glucosidase inhibitors

D Şöhretoğlu, G Renda, R Arroo, J Xiao, S Sari - Efood, 2023 - Wiley Online Library
Abstract α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat
type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a …

A Review on Extracts, Chemical Composition and Product Development of Walnut Diaphragma Juglandis Fructus

Y Zhan, M Ma, Z Chen, A Ma, S Li, J Xia, Y Jia - Foods, 2023 - mdpi.com
Walnuts are one of the world's most important nut species and are popular for their high
nutritional value, but the processing of walnuts produces numerous by-products. Among …

New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation

J Lin, D Xiao, L Lu, B Liang, Z Xiong, X Xu - Journal of Molecular Structure, 2023 - Elsevier
Abstract α-Glucosidase is an important therapeutic target of diabetes mellitus. To find potent
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …

Chromone-based benzohydrazide derivatives as potential α-glucosidase inhibitor: Synthesis, biological evaluation and molecular docking study

M Fan, W Yang, Z Peng, Y He, G Wang - Bioorganic Chemistry, 2023 - Elsevier
In order to find new α-glucosidase inhibitors with high efficiency and low toxicity, novel
chromone-based benzohydrazide derivatives 6a-6s were synthesized and characterized …

Pingchong Jiangni recipe through nerve growth factor/transient receptor potential vanilloid 1 signaling pathway to relieve pain in endometriosis model rats

D Chen, Y Ren, J Jin, S Liu, X Zhan, X Li… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Pingchong Jiangni recipe (PJR) is often used in
the treatment of endometriosis (EM). This formula has been clinically validated by the State …

Exploring plant-based alpha-glucosidase inhibitors: promising contenders for combatting type-2 diabetes

S Kumari, R Saini, A Bhatnagar… - Archives of Physiology …, 2023 - Taylor & Francis
Objective: This systematic review aimed to provide comprehensive details on the α-G
inhibitory potential of various bioactive compounds derived from natural sources. Methods: A …

Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway

X Han, W Zhou, J Zhang, Y Tu, J Wei, R Zheng… - International …, 2023 - Elsevier
Diabetic cardiomyopathy (DCM) is a challenging diabetic complication that manifests as
chronic inflammation. Yet, the mechanism underlying diabetes-associated myocardial injury …

Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation

B Liang, D Xiao, SH Wang, X Xuetao - European Journal of Medicinal …, 2024 - Elsevier
In the quest for potent α-glucosidase inhibitors to combat diabetes, a series of novel
thiosemicarbazide-based β-carboline derivatives (CTL1∼ 36) were synthesized and …

The chemical constituents of Diaphragma Juglandis Fructus and their inhibitory effect on α-Glucosidase activity

J Tan, Y Cheng, S Wang, J Li, H Ren, Y Qiao, Q Li… - Molecules, 2022 - mdpi.com
In our current investigation, 37 constituents (1–37), including 11 megastigmanes (1–11), 17
flavonoids (12–28) and 9 phenylpropanoids (29–37), were isolated from a 70%-EtOH extract …