Differences in gut microbiota composition have been observed in patients with major
depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal …

Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …

The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can
interact with endothelial cells. However, no studies demonstrated the direct effect of the …

Gasdermin E (GSDME), as the major executive protein of pyroptosis, has been considered
to be linked to antitumor immunity in recent years. However, the role of GSDME in oral …

Fatty acid composition in the Western diet has shifted from saturated to polyunsaturated fatty
acids (PUFAs), and specifically to linoleic acid (LA, 18: 2), which has gradually increased in …

Neuroinflammation impacts the brain and cognitive behavior through microglial activation. In
this study, we determined the temporal sequence from microglial activation to synaptic …

Coronaviruses have been the causative agent of three epidemics and pandemics in the past
two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing …

The translation of successful preclinical and clinical proof-of-concept studies on
cardioprotection to the benefit of patients with reperfused acute myocardial infarction has …

Microplastics (MPs) pollution is arousing growing attention, yet knowledge about its
occurrence in amphibians is scant to date. With this study, we aimed to determine whether …

Background: Cardiac remodeling in heart failure involves macrophage-mediated immune
responses. Recent studies have shown that a PRR (pattern recognition receptor) called …