Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …

Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin
resistance and diabetes, but mechanisms underlying this relationship are unclear. Although …

Chronic inflammation plays an important role in the development of metabolic diseases.
These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty …

Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …

Obesity, manifested by increased adiposity, represents a main cause of morbidity in the
developed countries, causing increased risk of insulin resistance and type 2 diabetes …

Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy,
hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a …