CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products
Y Tu, L Tan, H Tao, Y Li, H Liu - Phytomedicine, 2023 - Elsevier
Background Monitoring target engagement at various stages of drug development is
essential for natural product (NP)-based drug discovery and development. The cellular …
essential for natural product (NP)-based drug discovery and development. The cellular …
Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases
Post-transcriptional RNA modification is an emerging epigenetic control mechanism in cells
that is important in many different cellular and organismal processes. N6-methyladenosine …
that is important in many different cellular and organismal processes. N6-methyladenosine …
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: Based on transcriptomics and …
Y Huang, W Luo, S Chen, H Su, W Zhu, Y Wei, Y Qiu… - Phytomedicine, 2023 - Elsevier
Background Effective drugs for the treatment of hepatic fibrosis have not yet been identified.
Isovitexin (IVT) is a promising hepatoprotective agent owing to its efficacy against acute liver …
Isovitexin (IVT) is a promising hepatoprotective agent owing to its efficacy against acute liver …
[HTML][HTML] METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation
C Lin, T Li, Y Wang, S Lai, Y Huang, Z Guo… - Cell Death & …, 2023 - nature.com
The aim of the present study was to clarify the mechanism of how METTL3 regulated
pancreatic ductal adenocarcinoma (PDAC) progression by m6A modification of its …
pancreatic ductal adenocarcinoma (PDAC) progression by m6A modification of its …
An ultra‐high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry identification and characterization of the active constituents from …
Z Tan, S Chen, M Zhang, X Qu, T Li… - Journal of …, 2023 - Wiley Online Library
Abrus mollis Hance is a traditional Chinese medicine that is widely used to treat acute and
chronic hepatitis, steatosis, and fibrosis. Its therapeutic qualities of it have long been …
chronic hepatitis, steatosis, and fibrosis. Its therapeutic qualities of it have long been …
Comprehensive analysis of transcriptome‐wide M6A methylation for hepatic ischaemia reperfusion injury in mice
Y Hua, X Li, B Yin, J Huang, S Lu, C Wang, S Ke… - Epigenetics, 2023 - Taylor & Francis
ABSTRACT N6-Methyladenosine (m6A) plays key roles in the regulation of biological
functions and cellular mechanisms for ischaemia reperfusion (IR) injury in different organs …
functions and cellular mechanisms for ischaemia reperfusion (IR) injury in different organs …
Antimicrobial and antibiofilm activity of isoorientin against carbapenem non-sensitive Escherichia coli from raw milk of goats
J Zuo, L Liu, S Hou, X Liu, J Teng, P Li… - Journal of Animal …, 2023 - academic.oup.com
Carbapenemase-producing E. coli is a grave public health concern as the potential
emergence of resistant strains and their transmission. Isoorientin belongs to a potential …
emergence of resistant strains and their transmission. Isoorientin belongs to a potential …