Pain is the leading cause of medical consultations and occurs in 50–70% of emergency
department visits. To date, several drugs have been used to manage pain. The clinical use …

Abstract Purpose of Review Suicidal behaviours are a challenge for a medical system and
public health, partly due to the current lack of evidence-based, effective, rapid tools for …

The prefrontal cortex (PFC) regulates a wide range of sensory experiences. Chronic pain is
known to impair normal neural response, leading to enhanced aversion. However, it …

Postpartum depression is a common disabling psychosocial disorder that could have
adverse effects on the life of the mother, infant, and family. The present study was conducted …

Chronic pain affects one in five adults. It is not only a major cause of disability for individual
patients but also a driver of costs for entire healthcare systems. Treatment of pain remains a …

The purpose of this review is to report on the perioperative uses of intravenous (IV) ketamine
based on literature from the last five years (2018–2022). We searched MEDLINE, Embase …

Ketamine is a potent sedative and dissociative anesthetic agent that has been used
clinically for over 50 years since it was first developed in the 1960 s as an alternative to …

Background Mastectomies are commonly performed and strongly associated with chronic
postsurgical pain (CPSP), more specifically termed postmastectomy pain syndrome (PMPS) …

Introduction: Acute pain from episodic vaso-occlusion (VOC) spans the lifespan of almost
everyone with sickle cell disease (SCD), while additional chronic pain develops in …

Methods: To reproduce OIH in a model of postoperative pain, rats received successive
doses of fentanyl subcutaneously and underwent an incision in the paw. In an attempt to …