Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Synucleinopathies are characterized by the accumulation of α-synuclein (α-Syn) aggregates
in the brain. Positron emission tomography (PET) imaging of synucleinopathies requires …

Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to
cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's …

The present advances in biology are related to progress in genomics, proteomics, and other
“-omics”, including glycomics, working with a large amount of data regarding human and …

Objective: To prospectively examine whether higher intakes of total flavonoids and their
subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were …

Many chronic human diseases, including multiple neurodegenerative diseases, are
associated with deleterious protein aggregates, also called protein amyloids. One common …

Parkinson's disease is an age-related movement disorder characterized by the presence in
the mid-brain of amyloid deposits of the 140-amino-acid protein AS (α-synuclein). AS …

Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …

Protein misfolding diseases are becoming increasingly prevalent, yet there are very few
effective pharmacological treatments. The onset and progression of these diseases is …