The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …

Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

Cardiovascular disease (CVD) remains the leading cause of mortality globally, so further
investigation is required to identify its underlying mechanisms and potential targets for its …

For more than half a century, metabolic perturbations have been explored in the failing
myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by …

Replicative capacity of somatic cells is limited. It indicates that aging also develops at the
cellular level, and this is described as “cellular senescence”. Senescent cells become …

The histone demethylase PHF8 has been implicated in multiple pathological disorders,
including X-linked mental retardation and tumorigenesis. However, it is not clear how the …

Background—The ubiquitin proteasome system maintains a dynamic equilibrium of proteins
and prevents accumulation of damaged and misfolded proteins, yet its role in human cardiac …

Rationale: Mutations in the LMNA gene, encoding LMNA (lamin A/C), are responsible for
laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in …

In the cell, the proteasome and lysosomes represent the most important proteolytic
machineries, responsible for the protein degradation in the ubiquitin–proteasome system …

Rationale: LMNA (Lamin A/C), a nuclear membrane protein, interacts with genome through
lamin-associated domains (LADs) and regulates gene expression. Mutations in the LMNA …