Amyloid formation as a protein phase transition
The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …
is associated with both functional biology and the development of a number of disorders …
[HTML][HTML] Visualizing and trapping transient oligomers in amyloid assembly pathways
Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …
towards amyloid disease. However, understanding how such intermediates form, their …
[HTML][HTML] Atomic force microscopy for single molecule characterisation of protein aggregation
The development of atomic force microscopy (AFM) has opened up a wide range of novel
opportunities in nanoscience and new modalities of observation in complex biological …
opportunities in nanoscience and new modalities of observation in complex biological …
Lipids uniquely alter rates of insulin aggregation and lower toxicity of amyloid aggregates
Amyloid formation is a hallmark of many medical diseases including diabetes type 2,
Alzheimer's and Parkinson diseases. Under these pathological conditions, misfolded …
Alzheimer's and Parkinson diseases. Under these pathological conditions, misfolded …
Amyloid aggregation simulations: challenges, advances and perspectives
B Strodel - Current opinion in structural biology, 2021 - Elsevier
In amyloid aggregation diseases soluble proteins coalesce into a wide array of undesirable
structures, ranging through oligomers and prefibrillar assemblies to highly ordered amyloid …
structures, ranging through oligomers and prefibrillar assemblies to highly ordered amyloid …
Unsaturation in the fatty acids of phospholipids drastically alters the structure and toxicity of insulin aggregates grown in their presence
M Matveyenka, S Rizevsky… - The journal of physical …, 2022 - ACS Publications
Lipid bilayers play an important role in the pathological assembly of amyloidogenic proteins
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …
Recent advancements of nanomedicine in neurodegenerative disorders theranostics
S Mukherjee, VS Madamsetty… - Advanced Functional …, 2020 - Wiley Online Library
Recent times have witnessed an upsurge in the incidence of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and …
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and …
Complete aggregation pathway of amyloid β (1-40) and (1-42) resolved on an atomically clean interface
To visualize amyloid β (Aβ) aggregates requires an uncontaminated and artifact-free
interface. This paper demonstrates the interface between graphene and pure water (verified …
interface. This paper demonstrates the interface between graphene and pure water (verified …
The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates
M Matveyenka, S Rizevsky, D Kurouski - FEBS letters, 2022 - Wiley Online Library
Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling
and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies …
and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies …
Pathways of amyloid-β aggregation depend on oligomer shape
One of the main research topics related to Alzheimer's disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …