Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead.
They noted sustained cell-cycle arrest after repeated subculturing of human primary cells …

Dysregulated hyperinflammatory response is key in the pathogenesis in patients with severe
COVID-19 leading to acute respiratory distress syndrome and multiorgan failure. Whilst …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder that affects 7-10 million
individuals worldwide. A common early symptom of PD is olfactory dysfunction (OD), and …

Objective The multi-systemic inflammation as a result of COVID-19 can persevere long after
the initial symptoms of the illness have subsided. These effects are referred to as Long …

This study evaluated the effects of Rorippa cantoniensis (Lour.) ohwi extract (RCE) on
factors associated with inflammation-related skin lesions in RAW 264.7 and HaCaT cells …

TNF and IFN-γ trigger cell damage during SARS CoV-2 infection; these cytokines can
induce senescence and a cell death process called PANoptosis. This study included 138 …

Abstract Background Creeping fat (CrF) has been recognized to play a positive role in
Crohn's disease (CD) progression, yet the cellular compositions within mesenteric adipose …

Target discovery is crucial for the development of innovative therapeutics and diagnostics.
However, current approaches often face limitations in efficiency, specificity, and scalability …