Many human birth defects and neurodevelopmental disorders are caused by loss-of-function
mutations in a single copy of transcription factor (TF) and chromatin regulator genes …

The discovery of the FOXP2 transcription factor, and its implication in a rare severe human
speech and language disorder, has led to two decades of empirical studies focused on …

Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants
robustly associated with the trait have not been identified. The present study by the Broad …

Osteoarthritis (OA) and major depression (MD) are two debilitating disorders that frequently
co-occur and affect millions of the elderly each year. Despite the greater symptom severity …

The forkhead box protein P2 (Foxp2), initially identified for its role in speech and language
development, plays an important role in neural development. Previous studies investigated …

Transcription factors regulate gene expression by binding to DNA. They have disordered
regions and specific DNA-binding domains. Binding to DNA causes structural changes …

Background Despite their vast biological implication, the relevance of short tandem repeats
(STRs)/microsatellites to the protein-coding gene translation initiation sites (TISs) remains …

Neural stem cells (NSCs) in the adult and aged brain are largely quiescent, and require
transcriptional reprogramming to re‐enter the cell cycle. However, the mechanisms …

Unique human features, such as complex language, are the result of molecular evolutionary
changes that modified developmental programs of our brain. The human-specific evolution …

Multiple factors involve speech and language. Investigating animal models, mainly through
songbirds, has allowed a better understanding of the verbal communication process …