Abstract Background and Aims This Rome Foundation Working Team Report reflects the
consensus of an international, interdisciplinary team of experts regarding the use of …

Over the past few years, scientific interest in the gut–brain axis (ie, the bidirectional
communication system between the gastrointestinal tract and the brain) has exploded …

Somatic and visceral nociceptive signals travel via different pathways to reach the spinal
cord. Additionally, signals regulating visceral blood flow and gastrointestinal tract (GIT) …

Different pain types may be encoded in different brain circuits. Here, we examine similarities
and differences in brain processing of visceral and somatic pain. We analyze data from …

Background Inflammation and depressed mood constitute clinically relevant vulnerability
factors for enhanced interoceptive sensitivity and chronic visceral pain, but their putative …

The formation and persistence of negative pain-related expectations by classical
conditioning remain incompletely understood. We elucidated behavioural and neural …

Background Studies using somatic pain models have shown the hypoalgesic effects of slow,
deep breathing. We evaluated the effect of slow, deep breathing on visceral pain and …

Despite growing interest in the role of stress mediators in pain chronicity, the effects of the
stress hormone cortisol on acute pain remain incompletely understood. In a randomized …

Compared to the field of anxiety research, the use of fear conditioning paradigms for
studying chronic pain is relatively novel. Developments in identifying the neural correlates of …

Abstract Development and validation of pain biomarkers has become a major issue in pain
research. Recent advances in multimodal data acquisition have allowed researchers to …